Vulnerability to climate change is typically assessed using environmental or economic metrics that underrepresent the psychological significance of loved places. Over recent years, emotional and psychological connections to place (or ‘sense of place’) have been recognised as powerful drivers of mental health and wellbeing, particularly for individuals who retain close living and working relationships to the land. In Australia, many family farmers retain generational bonds to their farming environments, as well as a high dependence upon seasonal weather conditions for their lifestyles and livelihoods. This research examined the psychological significance of family farmers’ sense of place, as well as climate change impacts on farmers’ place-related mental health and wellbeing. The research employed a community-based qualitative case study located in the central Western Australian Wheatbelt. Twenty-two family farmers took part in a three-part semi-structured interview series that investigated their sense of place and lived experiences of climate change. Interview data was supplemented with various other qualitative data collection methods (e.g. key informant interviews, media and document analysis, photography). Thematic analysis of the data revealed observed patterns of climate change and climate-related environmental degradation to be significant mental health stressors for family farmers, eliciting feelings of place-based distress (e.g. meteoranxiety and solastalgia), as well as environmentally produced forms of depression and anxiety. The research findings offer novel insights into the mental health risks associated with a changing climate for Australian family farmers. Strategies to reduce farmers’ exposure to climate-related mental health risks are discussed.